Sandia partnered with the Scripps Institution of Oceanography, the naval architect firm Glosten and the class society DNV GL to assess the technical, regulatory and economic feasibility of a hydrogen fuel-cell coastal research vessel. Feasibility was found for a 10-knot vessel with 2400 nautical mile range, able to perform 14 Scripps science missions, and could be refueled with liquid hydrogen at 4 different ports of call along the U.S. west coast. An analysis was also performed of the criteria pollutant emissions as well as greenhouse gas emissions. The Zero-V has zero emissions on the vessel itself. Dramatic reductions in both types of emissions along the hydrogen production and delivery pathways could be achieved using renewable liquid hydrogen. No “show-stopping” issues were identified by either DNV GL or the United States Coast Guard. The feasibility of the Zero-V, as well as the ability to refuel it with ~ 11,000 kg of hydrogen, has implications for large hydrogen fueled vessels such as cargo vessels and cruise ships. This work was funded by the Maritime Administration (MARAD) within the U.S. Department of Transportation.